Repeatability and reproducibility of a hyperspectral imaging system for in vivo color evaluation.

BACKGROUND: Color imaging is a tried and true method for the evaluation of cosmetic and dermatological effects, but it fails to capture all the information in a scene's spectral reflectance. For this reason, there has been in recent years increasing interest in the use of imaging spectrometers for clinical studies and product evaluation. MATERIAL AND METHODS: We developed a novel HyperSpectral Imager (HSI) able to take in vivo full-face format images as a next generation instrument for skin color measurement and beyond. Here, we report part of the results of our first full-scale validation test of the HSI. We replicated a make-up foundation screening test by applying three products to a panel of 9 models and evaluated the product L∗ , a∗ , b∗ , and ∆E effect immediately after application relative to the bare skin condition. We repeated this test twice in order to study the repeatability of the HSI as an evaluation instrument and during each test two different operators duplicated the data acquisition so we can assess the reproducibility of the measurements. RESULTS: We find that the measurements from the HSI provide repeatability and reproducibility as good or better than those of our previous benchmark devices. CONCLUSION: From these results, we conclude that not only is the HSI suitable for use in color evaluation studies, but also that it gives operational advantages over the previous generation of evaluation instruments, as it provides a spectral measurement combined with good spatial resolution. This allows for analysis of color over an area and post hoc selection of study regions and so opens new possibilities for studies of complex in vivo phenomena which neither non-imaging spectrometers nor conventional cameras can pursue. This study also raises points for future work concerning proper inclusion of instrument uncertainty in comparisons of results between instruments and handling of systematic uncertainties from analyses based on a single area.

Performances of Kevlar and Polyethylene as radiation shielding on-board the International Space Station in high latitude radiation environment.

Passive radiation shielding is a mandatory element in the design of an integrated solution to mitigate the effects of radiation during long deep space voyages for human exploration. Understanding and exploiting the characteristics of materials suitable for radiation shielding in space flights is, therefore, of primary importance. We present here the results of the first space-test on Kevlar and Polyethylene radiation shielding capabilities including direct measurements of the background baseline (no shield). Measurements are performed on-board of the International Space Station (Columbus modulus) during the ALTEA-shield ESA sponsored program. For the first time the shielding capability of such materials has been tested in a radiation environment similar to the deep-space one, thanks to the feature of the ALTEA system, which allows to select only high latitude orbital tracts of the International Space Station. Polyethylene is widely used for radiation shielding in space and therefore it is an excellent benchmark material to be used in comparative investigations. In this work we show that Kevlar has radiation shielding performances comparable to the Polyethylene ones, reaching a dose rate reduction of 32 ± 2% and a dose equivalent rate reduction of 55 ± 4% (for a shield of 10 g/cm2).

Electrophysiological responses of the mouse retina to 12C ions.

Phosphenes ("light flashes") have been reported by most astronauts on space missions and by healthy subjects whose eyes were exposed to ionizing radiation in early experiments in particle accelerators. The conditions of occurrence suggested retinal effects of heavy ions. To develop an in vivo animal model, we irradiated the eyes of anesthetized wild-type mice with repeated bursts of 12C ions delivered under controlled conditions in accelerator. 12C ions evoked electrophysiological retinal mass responses and activated the visual system as indicated by responses recorded from the visual cortex. No retinal immunohistological damage was detected. Mice proved a suitable animal model to study radiation-induced phosphenes in vivo and our findings are consistent with an origin of phosphenes in radiation activating the retina.

The Sileye-3/Alteino experiment for the study of light flashes, radiation environment and astronaut brain activity on board the International Space Station.

In this work we describe the instrument Sileye-3/Alteino, placed on board the International Space Station in April 2002. The instrument is constituted by an Electroencephalograph and a cosmic ray silicon detector. The scientific aims include the investigation of the Light Flash phenomenon, the measurement of the radiation environment and the nuclear abundance inside the ISS and the study of astronaut brain activity in space when subject to cosmic rays.